HRID1876254

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7054

Isatin

C8H5NO2

HCID72689

1-Naphthohydrazide

C11H10N2O

PRODUCTS

生成物

$结构：CCCCCCN1C(=O)/C(=N\NC(=O)c2cccc3ccccc23)c2ccccc21$

HCID178444723

未命名化合物

收率 58%

PROCEDURE

实验过程

The title compound was prepared using isatin 3 and 1-naphthhydrazide according to the synthetic method E. The product was purified by flash chromatography (eluent: AcOEt/Heptane: 3/7) to afford a yellow oil which crystalized. Yield: 58%. 1H NMR (DMSO-d6): δ 0.83 (t, J=6.9 Hz, 3H), 1.26 (m, 6H), 1.59-1.62 (m, 2H), 3.73 (t, J=6.9 Hz, 2H), 7.17-7.23 (m, 2H), 7.48 (t, J=7.2 Hz, 1H), 7.63-7.70 (m, 3H), 7.90 (d, J=6.6 Hz, 1H), 8.07 (t, J=6.6 Hz, 1H), 8.19 (d, J=8.7 Hz, 1H), 8.35 (br s, 1H), 13.51 (br s, 1H). 13C NMR (DMSO-d6): δ 14.29 (CH3), 22.39 (CH2), 26.32 (CH2), 27.34 (CH2), 31.27 (CH2), 39.50 (CH2), 110.61 (CH), 119.61 (C), 121.22 (C), 123.65 (CH), 125.36 (CH), 125.51 (CH), 126.83 (CH), 127.20 (CH), 128.03 (CH), 129.04 (CH), 130.34 (C), 131.26 (C), 132.26 (CH), 133.82 (C), 143.49 (C═N), 161.34 (C═O). HRMS (ES+) calcd for C25H26N3O2 (M+H+), m/e, 400.2033; found, 400.2020.

WORKUP

后处理

customThe product was purified by flash chromatography (eluent: AcOEt/Heptane: 3/7)
customto afford a yellow oil which
customcrystalized