反应详情

To a mixture of ethyl 3-({[4-({cyclohexyl[2-ethyl-5-(tetrahydro-2H-thiopyran-4-yl)thiophen-3-yl]methyl}amino)phenyl]carbonyl}amino)propanoate (338 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N aqueous sodium hydroxide solution (1 mL), and the mixture was stirred at room temperature for 3 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (1 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title compound (296 mg, 93%) as a white solid.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in water (10 mL)
3. addition1N hydrochloric acid (1 mL) was added at 0° C
4. filtrationThe resulting precipitate was collected by filtration