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HRID1878721

反应详情

EQUATION

反应方程式

HRID 1878721 的结构方程式

REACTANTS

反应物

2
结构：F.c1ccncc1
HCID64774

Pyridinium fluoride

C5H6FN

结构：CC(C)(C)OC(=O)Nc1ccc(=O)n(C(C)(C)CO[Si](C)(C)C(C)(C)C)c1
HCID59843016

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)Nc1ccc(=O)n(C(C)(C)CO)c1
HCID69231018

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

To a stirred suspension of tert-butyl 1-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-6-oxo-1,6-dihydropyridin-3-ylcarbamate (800 mg, 2017 μmol) in ACN (10 mL) was added hydrogen fluoride pyridine (484 μl, 24206 μmol). The reaction mixture was stirred for 1 h and quenched with dry silica. The solvent was removed under reduced pressure and the product purified on silica (40 g) eluting with 0-5% MeOH/CH2Cl2. MS (ESI pos. ion) m/z (MH+): 283. Calc'd exact mass for C14H22N2O4: 282.

WORKUP

后处理

  1. customquenched with dry silica
  2. customThe solvent was removed under reduced pressure
  3. customthe product purified on silica (40 g)
  4. washeluting with 0-5% MeOH/CH2Cl2