反应详情

The title compound was prepared in a manner analogous to the compound 149 from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid and 3-fluoro-4-(4-methylpiperazin-1-yl)aniline with yield 52.4 mg (41%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.60 (br. s., 6 H) 1.99 (s, 2 H) 2.22 (s, 3 H) 2.40-2.51 (m, 4 H) 2.98 (br. s., 4 H) 3.97 (s, 3 H) 4.22 (t, 2 H) 4.79 (m, 1 H) 7.03 (t, J=9.35 Hz, 1 H) 7.45 (dd, J=8.72, 1.64 Hz, 1 H) 7.54-7.78 (m, 3 H) 8.04 (s, 1 H) 8.28 (s, 1 H) 8.36 (d, J=8.34 Hz, 1 H) 10.11 (s, 1 H). [M+H] calc'd for C32H37F2N8O3, 639; found 639.