反应详情

Following the procedure as describe in Example 16, making variations as required to replace 2-(3-((2,2-difluorocyclopropyl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid with 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid to react with (2-isopropylthiazol-4-yl)methanamine, the title compound was obtained as a colourless solid in 61% yield: mp 151-153° C.; 1H NMR (300 MHz, DMSO-d6) δ 8.81 (t, J=5.8 Hz, 1H), 8.73 (s, 1H), 7.33-7.30 (m, 2H), 7.20 (s, 1H), 7.19-7.13 (m, 2H), 4.97 (s, 2H), 4.44 (d, J=6.0 Hz, 2H), 3.63-3.53 (m, 1H), 2.54 (s, 3H), 1.28 (d, J=6.0 Hz, 6H); 13C NMR (75 MHz, DMSO-d6) δ 177.3, 162.2 (d), 161.3, 153.6, 151.8, 151.4, 150.2, 132.7 (d), 132.5, 130.4 (d), 123.0, 115.9, 114.1, 48.2, 42.3, 32.9, 23.3, 17.4; MS (ES+) m/z 472.9 (M+1).