N-[4-(4-methoxyphenyl)phenyl]methanesulfonamide → HCID 23508371, compound

HRID 1883701Notes

Reaction equation

HRID 1883701 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>ClCCCl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 23508422N-[4-(4-methoxyphenyl)phenyl]methanesulfonamide

Product 1

HCID 23508371HCID 23508371, compoundYield 46%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The procedure of Preparation Example 2 was repeated, except that 55 mg of N-(4′-methoxybiphenyl-4-yl)methanesulfonamide was used in place of 4′-methoxy-2-biphenylacetonitrile, and 1,2-dichloroethane was used in place of methylene chloride. The resulting crude product was purified by TLC (using a 6:1 mixture of chloroform and acetone as the developing solvent) to obtain 24 mg of N-(4′-hydroxybiphenyl-4-yl)-methanesulfonamide.

Workup

  1. customThe procedure of Preparation Example 2
  2. customThe resulting crude product was purified by TLC (
  3. additiona 6:1 mixture of chloroform and acetone as the developing solvent)

Sources & evidence

ORD record
ord-aedae06df69a4bc28a11fd69bd02a467
Source dataset
uspto-grants-2004_07
Patent number
US06762205B1

Reaction notes

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