1,4'-Bipiperidine → 1'-[6-(Pyridin-3-yl)pyridazin-3-yl]-1,4'-bipiperidine

HRID 1887178Notes

Reaction equation

HRID 1887178 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1.[N:14]1([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[N:10]1[CH:11]=[CH:12][CH:13]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:23]3[CH2:24][CH2:25][CH:20]([N:14]4[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]4)[CH2:21][CH2:22]3)=[CH:7][CH:6]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 786071,4'-BipiperidineHCID 167324353-Chloro-6-(pyridin-3-yl)pyridazine

Product 1

HCID 580065681'-[6-(Pyridin-3-yl)pyridazin-3-yl]-1,4'-bipiperidine

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-(pyridin-3-yl)-pyridazine and 4-piperidinopiperidine. 1H NMR (400 MHz, CD3OD) δ 9.47 (d, 1H), 9.11 (dt, 1H), 8.93 (d, 1H), 8.40 (d, 1H), 8.15 (q, 1H), 7.94 (d, 1H), 4.66 (d, 2H), 3.66 (m, 1H), 3.58 (d, 2H), 3.36 (t, 2H), 3.08 (t, 2H), 2.38 (d, 2H), 1.80-2.00 (m, 7H), 1.54 (m, 1H).

Sources & evidence

ORD record
ord-fcfb01bf151144a287d88b1aa1aa0ad1
Source dataset
uspto-grants-2013_08
Patent number
US08501739B2

Reaction notes

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