反应详情

Following the procedure as described in Example 22, making variation only as required to use (1H-pyrazol-3-yl)methanamine in place of benzo[b]thiophen-2-ylmethanamine to react with 2-(4-(benzyloxy)-2-oxopyridin-1(2H)-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as a colorless solid in 43% yield: 1H NMR (300 MHz, DMSO-d6) δ 12.63 (br s, 1H), 8.74-8.54 (m, 2H), 7.63-7.31 (m, 6H), 6.38 (dd, J=8.1, 2.5 Hz, 1H), 6.22 (d, J=2.5 Hz, 1H), 6.13 (d, J=1.0 Hz, 1H), 5.15 (s, 2H), 4.37 (d, J=5.6 Hz, 2H), 2.53 (s, 3H); MS (ES+) m/z 422.2 (M+1).