Cyclobutanamine, hydrochloride (1:1) → HCID 178441269, compound

HRID 1888698Notes

Reaction equation

HRID 1888698 reaction equation
[CH2:1]([C:5]1=[CH:6][N:7]([C:24]([CH3:27])([CH3:26])[CH3:25])[S:8]/[C:9]/1=[N:10]\[C:11]([C@:13]1([CH3:23])[CH2:17][CH2:16][C@H:15]([C:18]([OH:20])=O)[C:14]1([CH3:22])[CH3:21])=[O:12])[CH2:2][CH2:3][CH3:4].Cl.[CH:29]1([NH2:33])[CH2:32][CH2:31][CH2:30]1>>[CH2:1]([C:5]1=[CH:6][N:7]([C:24]([CH3:26])([CH3:25])[CH3:27])[S:8]/[C:9]/1=[N:10]\[C:11]([C@:13]1([CH3:23])[CH2:17][CH2:16][C@H:15]([C:18]([NH:33][CH:29]2[CH2:32][CH2:31][CH2:30]2)=[O:20])[C:14]1([CH3:21])[CH3:22])=[O:12])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 12618374Cyclobutanamine, hydrochloride (1:1)HCID 178441278HCID 178441278, compound

Product 1

HCID 178441269HCID 178441269, compound

Procedure

The product from Example 173 and cyclobutylamine hydrochloride (Aldrich) were processed using the method described in Example 178 to afford the title compound. 1H NMR (DMSO-d6) δ 0.00 (s, 3H), 0.44 (t, J=7.3 Hz, 3H), 0.74 (s, 3H), 0.77 (s, 3H), 0.80-0.98 (m, 3H), 1.11 (s, 9H), 1.11-1.21 (m, 5H), 1.32-1.57 (m, 3H), 1.62-1.72 (m, 2H), 2.13-2.21 (m, 3H), 2.26-2.36 (m, 1H), 3.67-3.80 (m, 1H), 7.32 (d, J=7.7 Hz, 1H), 8.04 (s, 1H). (ESI+) m/z 448 (M+H)+. Anal. calcd. for C25H41N3O2S: C, 67.07; H, 9.23; N, 9.39. Found: C, 66.48; H, 9.40; N, 9.24.

Sources & evidence

ORD record
ord-9924b705d99841788595d1d8f90bfef5
Source dataset
uspto-grants-2013_08
Patent number
US08501794B2

Reaction notes

Loading…