反应详情

[8-(4-Methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-(3-methoxy-phenyl)-amine was prepared from (8-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-(3-methoxy-phenyl)-amine (200.0 mg, 0.6266 mmol) and (4-methylsulfonylphenyl)boronic acid (150.0 mg, 0.7499 mmol) with Pd(dppf)Cl2 (50.0 mg) as the catalyst in a manner analogous to Step 2c and was isolated as a yellow solid (0.097 g, 39%). MP=204-206° C. 1H NMR (400 MHz, CDCl3, δ, ppm): 8.50 (d, J=6.1 Hz, 1H), 8.24 (d, J=7.8 Hz, 2H), 8.08 (d, J=7.7 Hz, 2H), 7.66 (d, J=7.4 Hz, 1H), 7.37 (s, 1H), 7.28-7.22 (m, 1H), 7.08-7.00 (m, 2H), 6.92 (s, 1H), 6.58 (d, J=7.6 Hz, 1H), 3.86 (s, 3H), 3.10 (s, 3H). MS=395 (MH)+.