反应详情

6-(Benzyloxy)-N2-phenylpyridine-2,3-diamine (68 mg, 0.23 mmol) was dissolved in trimethyl orthoacetate (5.0 mL) and TFA (10 μL) was added. The mixture was stirred at room temperature for 2 h and concentrated in vacuo. The benzyl group of the residue was then removed as described in Example 1.11, Step B to give the title compound as a white solid (15 mg). 1H NMR (400 MHz, DMSO-d6) δ ppm 2.35 (s, 1H), 6.51 (d, J=8.6 Hz, 1H), 7.48-7.55 (m, 3H), 7.57-7.63 (m, 2H), 7.84 (d, J=8.6 Hz, 1H).

1. concentrationconcentrated in vacuo
2. customThe benzyl group of the residue was then removed