反应详情

A mixture of the previously prepared 4-(2-tert-butyl-4-nitro-1H-pyrrole-5-carbonyl)-3,3-dimethylpiperazin-2-one (80 mg, 0.25 mmol) dissolved in methanol (2 mL) and Pd on charcoal (10% w/w, 20 mg) was shaken under hydrogen atmosphere in a Parr shaker at 50 psi for 18 hours. The reaction was filtered through celite, the residue concentrated under vacuum to afford 68 mg of the desired 4-(4-amino-2-tert-butyl-1H-pyrrole-5-carbonyl)-3,3-dimethylpiperazin-2-one as a yellow oil.

1. filtrationThe reaction was filtered through celite
2. concentrationthe residue concentrated under vacuum