反应详情

The title compound was prepared in the same way as the Compound of Example 274 but replacing Compound 274c with Compound 294a and 1-bromo-3,5-difluorobenzene with 3-iodofluorobenzene and adding 1 molar equivalent of tetrabutylammonium fluoride monohydrate to the starting reaction mixture. Purification by automated flash chromatography (Horizon™-Biotage) PE-EtOAc 100:30, then by CHCl3 followed by a final purification by preparative RP LC-MS chromatography, using MS-C18 XTerra column 30×50 mm eluting with ammonium bicarbonate 20 mM pH 8 buffer-acetonitrile gradient afforded a colourless oil. Yield: 20.4%. LCPREP. Colourless oil. Yield: 20.4%

1. customto the starting reaction mixture
2. customPurification by automated flash chromatography (Horizon™-Biotage) PE-EtOAc 100:30
3. custompurification by preparative RP LC-MS chromatography
4. washeluting with ammonium bicarbonate 20 mM pH 8 buffer-acetonitrile gradient
5. customafforded a colourless oil