反应详情

The title compound was prepared from Compound 2a (in place of Compound 274c) following the procedure described for the compound of Example 274, using 2,6-dibromopyridine instead of 1-bromo-3,5-difluorobenzene and adding 1 molar equivalent of tetrabutylammonium fluoride monohydrate to the starting reaction mixture. After the work-up, the residue was purified by automated flash liquid chromatography (Horizon™-Biotage) eluting with PE-EtOAc gradient from 10:0 to 8:2 affording the title product. White solid. Yield: 68%.

1. customto the starting reaction mixture
2. customAfter the work-up, the residue was purified by automated flash liquid chromatography (Horizon™-Biotage)
3. washeluting with PE-EtOAc gradient from 10:0 to 8:2 affording the title product