反应详情

The title compound was prepared from tert-butyl 4-{5-[2-(methylamino)pyrimidin-4-yl]-4-phenyl-1H-imidazol-1-yl}piperidine-1-carboxylate (C25) according to the general procedure for the synthesis of 4-(4-phenyl-1-piperidin-4-yl-1H-imidazol-5-yl)pyrimidine (C23) in Example 11. In this case, after the organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure, the product was obtained as a white solid. Yield: 174 mg, 0.520 mmol, 100%. APCI m/z 335.0 (M+1). 1H NMR (400 MHz, CD3OD) δ 2.09-2.20 (m, 2H), 2.37 (br d, J=12 Hz, 2H), 2.97 (s, 3H), 3.0-3.04 (m, 2H), 3.41-3.46 (m, 2H), 4.93 (tt, J=12, 4 Hz, 1H, assumed; partially obscured by water signal), 6.33 (d, J=5.1 Hz, 1H), 7.27-7.35 (m, 3H), 7.37-7.41 (m, 2H), 8.05 (s, 1H), 8.09 (d, J=5.1 Hz, 1H).

1. dry with materialIn this case, after the organic layers were dried over magnesium sulfate
2. filtrationfiltered
3. concentrationconcentrated under reduced pressure
4. customthe product was obtained as a white solid