反应详情

To a solution of 535 mg of tert-butyl 4-((2-((benzyloxy)carbonyl)hydrazino)carbonyl)-4-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)piperidine-1-carboxylate in 10 ml of methanol was added 200 mg of 20% palladium hydroxide on carbon, followed by stirring the reaction mixture at room temperature overnight under hydrogen atmosphere. Palladium catalyst was filtered off using Celite, washed with methanol, and the filtrate was concentrated in vacuo to give the title compound as a pale brown solid.

1. filtrationPalladium catalyst was filtered off
2. washwashed with methanol
3. concentrationthe filtrate was concentrated in vacuo