反应详情

The title compound was prepared following the procedure described for Step-1 of Intermediate-3 using methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate (1.10 g, 4.4 mmol), 1-chloro-3-fluoro-2-isothiocyanatobenzene (Intermediate-14, 1.0 g, 5.3 mmol), N,N-di-isopropyl carbodimide (0.5 mL) and acetonitrile (3.0 mL) to afford 1.0 g of the desired product. 1HNMR (DMSO-d6): δ 1.46 (s, 6H), 3.34 (s, 2H), 3.53 (s, 3H), 3.72 (s, 3H), 7.00 (m, 1H), 7.06 (s, 1H), 7.17 (t, J=9.3 Hz, 1H), 7.28 (d, J=8.4 Hz, 1H), 10.39 (s, 1H).

1. customThe title compound was prepared