Sodium Hydroxide → HCID 178432357, compound

HRID 1898348Notes

Reaction equation

HRID 1898348 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:22][C:21]2[C:16]3[N:17]=[C:18]([CH3:20])[O:19][C:15]=3[C:14]([C:23]([O:25]C)=[O:24])=[CH:13][C:12]=2[N:11]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[NH:9][C:10]1[NH:22][C:21]2[C:16]3[N:17]=[C:18]([CH3:20])[O:19][C:15]=3[C:14]([C:23]([OH:25])=[O:24])=[CH:13][C:12]=2[N:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178496996HCID 178496996, compound

Product 1

HCID 178432357HCID 178432357, compoundYield 74.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared following the procedure described for Step-5 of Intermediate-55 using methyl 7-[(2-chloro-6-fluorophenyl)amino]-2-methyl-8H-imidazo[4,5-e][1,3]benzoxazole-4-carboxylate (0.190 g, 0.508 mmol), MeOH (3.0 mL) and sodium hydroxide (0.101 g, 2.52 mmol) to afford 0.136 g of the desired product. 1HNMR (DMSO-d6): δ 2.60 (s, 3H), 7.35 (s, 2H), 7.44 (s, 1H), 7.64 (s, 1H), 12.0-13.0 (s, 3H); MS [M+H]+: 360.2.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-d64c6a7b5ecb489f9047e08cfd61e3b6
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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