反应详情

The title compound was prepared following the procedure described for step-1 of Intermediate-3 using methyl 5-amino-2,2-dimethyl-4-(methylamino)-2,3-dihydrobenzofuran-7-carboxylate (step-6 of Intermediate-49, 2.00 g, 8.0 mmol), 3,5-dichloro-4-isothiocyanatopyridine (Intermediate-2, 1.96 g, 9.6 mmol), N,N-di-isopropyl carbodimide (0.5 mL) and acetonitrile (10.0 mL) to afford 2.0 g of the desired product. 1HNMR (DMSO-d6): 1.47 (s, 6H), 3.49 (s, 2H), 3.56 (s, 3H), 3.73 (s, 3H), 7.10 (s, 1H), 8.46 (s, 2H), 10.79 (s, 1H).

1. customThe title compound was prepared