Hydrochloric Acid → HCID 178422741, compound

HRID 1898441Notes

Reaction equation

HRID 1898441 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[C:12]3[O:31][C:30]([CH3:33])([CH3:32])[CH2:29][C:13]=3[C:14]3[NH:18][C:17]([NH:19][C:20]4[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:27])=[N:16][C:15]=3[CH:28]=2)=[O:10])=[CH:4][CH:3]=1.Cl>C1COCC1>[ClH:26].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[C:12]3[O:31][C:30]([CH3:33])([CH3:32])[CH2:29][C:13]=3[C:14]3[NH:18][C:17]([NH:19][C:20]4[C:21]([Cl:27])=[CH:22][CH:23]=[CH:24][C:25]=4[Cl:26])=[N:16][C:15]=3[CH:28]=2)=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178422740HCID 178422740, compound

Product 1

HCID 178422741HCID 178422741, compoundYield 112.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared following the procedure described for Example-146 using N-(4-bromophenyl)-2-[(2,6-dichlorophenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxamide (Example-11, 0.100 g), THF and conc. HCl to afford 0.060 g of the desired product. 1HNMR (DMSO-d6): δ 1.56 (s, 6H), 2.20 (s, 2H), 7.51-7.57 (m, 3H), 7.64-7.74 (m, 5H), 9.81 (s, 1H), 12.0-13.0 (br, 3H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-100934a16af748e3bce8053d06a46f10
Source dataset
uspto-grants-2013_08
Patent number
US08519149B2

Reaction notes

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