反应详情

A stirred solution of 0.52 g of 1,3-dihydro-1-{trans-4-[4-(tert--butylcarbonyl)piperazin-1-yl]-1-cyclohexyl}-2H-benzimidazol-2-one in 15 mL of 1N HCl was heated to reflux for 1 h, cooled and basified with 6N NaOH. The basic mixture was extracted with 2×50 mL portions of chloroform. The combined organic extracts were dried over MgSO4 and concentrated under reduced pressure. After drying overnight under vacuum, there was obtained 0.28 g of 1,3-dihydro-1-{trans-4-[1-piperazinyl]-1-cyclohexyl}-2H-benzimidazol-2-one as a white solid: 1H NMR (400 MHz, CDCl3) 7.16-7.03 (m, 4H), 4.27 (m, 1H), 2.94 (m, 4H), 2.61 (m, 4H), 2.25 (m, 2H), 2.1 (d, 2H), 1.97 (d, 2H), 1.54 (m, 2H).

1. temperatureto reflux for 1 h
2. temperaturecooled
3. extractionThe basic mixture was extracted with 2×50 mL portions of chloroform
4. dry with materialThe combined organic extracts were dried over MgSO4
5. concentrationconcentrated under reduced pressure
6. customAfter drying overnight under vacuum