反应详情

In 50 ml of tetrahydrofuran and 100 ml of ethanol was dissolved 21 g (13×10-3 mole) of 2-nitro-3-{2-(2,4-di-t-amylphenoxy)butanamido}-4-chloro-6-benzamidophenol and hydrogenation was effected by using 1.2 g of Pd-C as a catalyst. The color of the nitro derivative disappeared in 4 hours, and the Pd-C was removed by filtration and a solvent was evaporated therefrom under reduced pressure, followed by extraction of the residue with ethyl acetate. The ethyl acetate layer was washed with an aqueous sodium hydrogen carbonate solution and then with water, and after drying over magnesium sulfate, ethyl acetate was evaporated. Yield: 20 g.

1. customthe Pd-C was removed by filtration
2. customa solvent was evaporated
3. extractionunder reduced pressure, followed by extraction of the residue with ethyl acetate
4. washThe ethyl acetate layer was washed with an aqueous sodium hydrogen carbonate solution
5. dry with materialwith water, and after drying over magnesium sulfate, ethyl acetate
6. customwas evaporated