反应详情

A solution of 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1,3-dimethyl-4-(2,4,6-trimethylphenylimino)-2(1H)pyrimidinone (5.0 g) in aqueous hydrobromic acid (47%) (50 ml) was refluxed for 1.5 hours. After being cooled to ambient temperature, the solution was neutralized with aqueous sodium hydroxide, and extracted with chloroform. The organic layer was washed with brine, dried over sodium sulfate, and evaporated. The resulting oil was crystallized from a mixture of diisopropyl ether and ethyl acetate (1:1 v/v) to give 3,4-dihydro-6-(3,4-dihydroxyphenyl)-1,3-dimethyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone (4.41 g).

1. extractionextracted with chloroform
2. washThe organic layer was washed with brine
3. dry with materialdried over sodium sulfate
4. customevaporated
5. customThe resulting oil was crystallized from a mixture of diisopropyl ether and ethyl acetate (1:1 v/v)