反应详情

To a solution of 3,4-dihydro-1,3-dimethyl-6-(4-ethoxycarbonylmethoxy-3-methoxyphenyl)-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone as obtained in Example 16 (0.67 g) in methanol (4 ml) was added 1N aqueous sodium hydroxide (2.38 ml) and the mixture was stirred at ambient temperature for 2 hours. After removal of the solvent, the residue was dissolved in water (5 ml), neutralized with 1-Nhydrochloric acid and extracted with chloroform. The organic layer was dried over sodium sulfate, evaporated, and triturated in diisopropyl ether to give 3,4-dihydro-6-(4-carboxymethoxy-3-methoxyphenyl)-1,3-dimethyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone (0.47 g).

1. customAfter removal of the solvent
2. dissolutionthe residue was dissolved in water (5 ml)
3. extractionextracted with chloroform
4. dry with materialThe organic layer was dried over sodium sulfate
5. customevaporated
6. customtriturated in diisopropyl ether