反应详情

A mixture of 6-[4-(3-benzylaminopropionamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (1.46 g, 0.004 mol), 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-2,3-epoxypropane (2.0 g, 0.008 mol) (British Pat. No. 1,515,978) and n-propanol was stirred and heated under reflux for 22 hours. Evaporation of the solvent under reduced pressure gave an oily residue which was purified by elution from a silica column with chloroform/methanol mixtures to give 6-[4-[3-[2-hydroxy-3-[4-(2-(cyclopropylmethoxy)ethyl]phenoxy]-N-benzylpropylamino]propionamido]phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone as a foam, 1.3 g, (38%); δ(CHCl3) 0.18 and 0.53 (2m, 4H, cyclopropylmethylene protons), 1.23 (d, 3H, dihydropyridazinone 5-methyl) ppm.

1. temperatureheated
2. temperatureunder reflux for 22 hours
3. customEvaporation of the solvent under reduced pressure
4. customgave an oily residue which
5. customwas purified by elution from a silica column with chloroform/methanol