反应详情

To a solution of 3.4 g of (S)-2-{[5-(3,3-Dimethyl-2-oxo-butoxy)-1-phenyl-1H-pyrazole-3-carbonyl]-amino}-pentanedioic acid 5-tert-butyl ester 1-methyl ester in 15 ml of THF, 6.5 ml of a 1 M aqueous NaOH solution was added. After stirring at RT upon completion of the reaction the mixture was acidified to pH 2 with diluted aqueous hydrochloric acid and extracted with DCM (3×100 ml). The combined organic phases were dried over MgSO4 and the solvents were removed under reduced pressure to yield a crystalline solid. Yield: 3.4 g

1. extractionextracted with DCM (3×100 ml)
2. dry with materialThe combined organic phases were dried over MgSO4
3. customthe solvents were removed under reduced pressure
4. customto yield a crystalline solid