反应详情

The procedure of Example 5.1 was repeated, but using instead of the compound prepared in Example 4.1 the compound {4-[(7-benzyl-2,7-diazatricyclo[4.4.0.03,8]dec-2-yl)-(3-methoxyphenyl)methyl]phenyl}-piperidin-1-yl-methanone of Example 4.6. The compound {4-[(2,7-diazatricyclo[4.4.0.03,8]dec-2-yl)-(3-methoxyphenyl)methyl]-phenyl}-piperidin-1-yl-methanone was obtained. Yield: quantitative. IR (nujol) (λ=cm−1) 1680 (C═O), 3100 (NH); 1H-NMR (CDCl3) δ 1.40-2.10 (m, 16H); 2.15-2.30 (m, 1H); 2.80-3.00 (m, 2H); 3.15-3.45 (m, 2H); 3.50-3.75 (m, 2H); 3.78 (s, 3H); 5.00-5.25 (m, 3H); 5.70-5.90 (m, 1H); 6.65-7.40 (m, 6H); 7.95-8.15 (m, 2H). Anal. calc. for C28H35N3O2: C, 75.47; H, 7.92; N, 9.43. Found: C, 75.23; H, 7.90; N, 9.41.