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HRID1912662

反应详情

EQUATION

反应方程式

HRID 1912662 的结构方程式

REACTANTS

反应物

2
结构：C[C@]12CCC(=O)CC1[C@@H](O[N+](=O)[O-])C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID69007680

未命名化合物

结构：C[C@]12CCCCC1[C@@H](O[N+](=O)[O-])C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID86635563

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CCC(=O)CC1[C@H](O[N+](=O)[O-])C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID69133309

未命名化合物

PROCEDURE

实验过程

Prepared in 75% yield from 3,3:17,17-bis(ethylendioxy)androstane-6α-yl nitrate following the procedure described above for the preparation of 3,17-dioxoandrostane-6α-yl nitrate (II-aa, Prepn 1). The crude product was purified by flash chromatography (SiO2, cyclo-hexane/acetone/CH2Cl2 70/15/15) to give II-ab. 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 5.24 (ddd, 1H), 2.72 (dd, 1H), 2.57-0.96 (m, 19H), 1.25 (s, 3H), 0.90 (s, 3H).

WORKUP

后处理

  1. customPrepared in 75% yield from 3,3
  2. customThe crude product was purified by flash chromatography (SiO2, cyclo-hexane/acetone/CH2Cl2 70/15/15)
  3. customto give II-ab