HRID1912702

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@]12CC[C@H]3[C@@H](CC(=O)[C@@]4(O)CCCC[C@]34C)[C@@H]1CC13OCCOC12OCCO3

HCID86635579

未命名化合物

结构：C[C@]12CCC(=O)CC1/C(=N/O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12

HCID87653583

未命名化合物

PRODUCTS

生成物

$结构：C[C@]12CC[C@H]3[C@@H](C/C(=N\O)[C@@]4(O)CCCC[C@]34C)[C@@H]1CC13OCCOC12OCCO3$

HCID154041431

未命名化合物

收率 85%

PROCEDURE

实验过程

17,17-Bis(ethylendioxy)-5α-hydroxy-6-(E)-hydroxyiminoandrostane was prepared in 85% yield from 3,3:17,17-bis(ethylendioxy)-5α-hydroxyandrostan-6-one by the procedure described above for the preparation of 6-(E)-hydroxyiminoandrostane-3,17-dione (II-at, Prepn. 20). The crude was purified by flash chromatography (SiO2, cyclohexane/acetone/CH2Cl2 70/15/15). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS: δ 10.45 (s, 1H), 4.33 (s, 1H), 3.96-3.69 (m, 8H), 2.96 (dd, 1H), 2.02-1.08 (m, 18H), 0.74 (s, 3H), 0.71 (s, 3H).

WORKUP

后处理

customThe crude was purified by flash chromatography (SiO2, cyclohexane/acetone/CH2Cl2 70/15/15)