Cyclohexylacetyl chloride → HCID 68750170, compound

HRID 1912976Notes

Reaction equation

[C:1]([C:5]1[C:6]([NH2:15])=[N:7][N:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH:16]1([CH2:22][C:23](Cl)=[O:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:1]([C:5]1[C:6]([NH:15][C:23](=[O:24])[CH2:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[N:7][N:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 2757989Cyclohexylacetyl chloride

HCID 68751373HCID 68751373, compound

Product 1

HCID 68750170HCID 68750170, compound

Procedure

The product from Example 178A and cyclohexylacetyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.91-1.03 (m, 2H), 1.11-1.30 (m, 3H), 1.43 (s, 9H), 1.59-1.80 (m, 6H), 2.16-2.18 (m, 2H), 2.29 (d, J=1.0 Hz, 1H), 8.38 (d, J=2.0 Hz, 1H), 8.75 (s, 1H), 9.58 (br s, 1H); MS (DCI) m/z 329 (M+H)+.

Sources & evidence

ORD record: ord-0cb67c7a81574d0b9effa715f9167099
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609669B2

Reaction notes

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