反应详情

Compound 1F was prepared from 6-(4-bromo-2-fluoro-phenyl)-4,5-difluoro-7-oxo-6,7-dihydro-imidazo[4′,5′:3,4]benzo[1,2-d]oxazole-8-sulfonic acid dimethylamide (I-24a: 100 mg, 0.203 mmol) and potassium trimethylsilonolate (39 mg, 0.305 mmol) using procedures analogous to those described above for Compound 1A to afford 30 mg of the product (29% yield). H1NMR (CDCl3, 300 MHz): δ 8.14 (s, 1H), 7.11-7.24 (m, 2H), 7.12 (dt, 1H), 6.79 (s, 1H), 6.58-6.48 (m, 1H), 2.90 (s, 6H). LCMS: 95.77%, m/z=462.9 (M−2). HPLC: 96.26%