反应详情

Compound 1G was prepared from 6-(4-bromo-2-fluoro-phenyl)-8-cyclopropanesulfonyl-4,5-difluoro-6,8-dihydro-imidazo[4′,5′:3,4]benzo[1,2-d]oxazol-7-one (I-25a: 120 mg, 0.245 mmol) and potassium trimethylsilonolate (46 mg, 0.368 mmol) using procedures analogous to those described above for Compound 1A to afford 20 mg of the product (17.8% yield). H1NMR (DMSO-d6, 300 MHz): δ 9.75 (s, 1H), 8.90 (s, 1H), 7.80 (s, 1H), 7.52 (dd, 1H), 7.17 (d, 1H), 6.80-6.68 (m, 1H), 2.68-2.60 (m, 1H), 0.90-0.82 (m, 2H), 0.80-0.70 (m, 2H). LCMS: 96.25%, m/z=460.0 (M−2). HPLC: 96.94%