HRID1915912

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)(C)OC(=O)Nc1sc(-c2ccccc2F)nc1C(=O)O

HCID67436713

未命名化合物

反应SMILES：CO[C@@H]1CCN(c2c(N)cnn2C)CC[C@H]1NC(=O)OC(C)(C)C

HCID86680114

未命名化合物

PRODUCTS

产物

反应SMILES：COC1CCN(c2c(NC(=O)c3nc(-c4ccccc4F)sc3N)cnn2C)CCC1N

HCID74983193

未命名化合物

收率 63%

PROCEDURE

实验过程

Following the procedure Example 101, reacting tert-butyl ((4R,5R)-1-(4-amino-1-methyl-1H-pyrazol-5-yl)-5-methoxyazepan-4-yl)carbamate and 5-((tert-butoxycarbonyl)amino)-2-(2-fluorophenyl)thiazole-4-carboxylic acid gave 324 (118 mg, 63% over two steps). 1H NMR (400 MHz, DMSO) δ 8.94 (s, 1H), 8.30 (t, J=8.2 Hz, 1H), 7.51 (s, 1H), 7.48-7.39 (m, 3H), 7.39-7.27 (m, 2H), 3.64 (s, 3H), 3.27 (s, 4H), 3.24-2.90 (m, 7H), 2.14-2.01 (m, 1H), 1.91-1.81 (m, 1H), 1.77-1.54 (m, 2H). LCMS (ES+) m/z 460 (M+1)