反应详情

8-Bromo-2,3,5,10,11,11a-hexahydro-1H-indolizino[7,6-b]indole (200 mg, 0.685 mmol) and 4-(4-chloro-2-fluorobenzyloxy)pyridin-2(1H)-one (173 mg, 0.685 mmol) were reacted following the procedure for Example 2 (step b) to provide the title compound (70 mg, 20%) as a brown solid: 1H NMR (300 MHz, DMSO-d6) δ 11.44 (s, 1H), 10.41 (s, 1H), 7.65-7.61 (t, J=8.2 Hz, 1H), 7.56-7.50 (m, 3H), 7.40-7.37 (dd, J=8.2, 1.9 Hz, 1H), 7.34-7.33 (d, J=1.7 Hz, 1H), 6.97-6.95 (dd, J=8.4, 1.8 Hz, 1H), 6.08-6.06 (dd, J=7.6, 2.7 Hz, 1H), 6.03-6.02 (d, J=2.7 Hz, 1H), 5.17 (s, 2H), 4.80-4.76 (dd, J=13.9, 2.2 Hz, 1H), 4.34-4.28 (m, 1H), 3.77-3.74 (m, 2H), 3.31-3.25 (m, 2H), 3.05-2.99 (m, 1H), 2.44-2.38 (m, 1H), 2.18-2.09 (m, 2H), 1.90-1.75 (m, 1H); ESI MS m/z 464 [M+H]+; HPLC (Method B) 97.3% (AUC), tR=13.9 min.