HRID1919031

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58043770

未命名化合物

结构：CC(=O)OCc1c(B2OC(C)(C)C(C)(C)O2)cc(F)cc1N1CCn2c(cc3c2CCCC3)C1=O

HCID58044205

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCc1c(-c2cn(C)c(=O)c(Nc3ccc4c(c3)CN(C)C4)n2)cc(F)cc1N1CCn2c(cc3c2CCCC3)C1=O

HCID67016429

未命名化合物

PROCEDURE

实验过程

Following the procedures as described for compound 148h and starting with 400 mg of 4-fluoro-2-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 210d and 278 mg of 5-bromo-1-methyl-3-(2-methylisoindolin-5-ylamino)pyrazin-2(1H)-one 231f, compound 231g was obtained as a yellow solid (258 mg, 51%). MS: [M+H]+ 611.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e2c9dadb309c43ff873830345a72264a
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618107B2
来源说明: uspto-grants-2013_12

反应 SMILES

[C:1]([O:4][CH2:5][C:6]1[C:11]([N:12]2[CH2:24][CH2:23][N:15]3[C:16]4[CH2:17][CH2:18][CH2:19][CH2:20][C:21]=4[CH:22]=[C:14]3[C:13]2=[O:25])=[CH:10][C:9]([F:26])=[CH:8][C:7]=1B1OC(C)(C)C(C)(C)O1)(=[O:3])[CH3:2].Br[C:37]1[N:38]=[C:39]([NH:45][C:46]2[CH:47]=[C:48]3[C:52](=[CH:53][CH:54]=2)[CH2:51][N:50]([CH3:55])[CH2:49]3)[C:40](=[O:44])[N:41]([CH3:43])[CH:42]=1>>[C:1]([O:4][CH2:5][C:6]1[C:11]([N:12]2[CH2:24][CH2:23][N:15]3[C:16]4[CH2:17][CH2:18][CH2:19][CH2:20][C:21]=4[CH:22]=[C:14]3[C:13]2=[O:25])=[CH:10][C:9]([F:26])=[CH:8][C:7]=1[C:37]1[N:38]=[C:39]([NH:45][C:46]2[CH:47]=[C:48]3[C:52](=[CH:53][CH:54]=2)[CH2:51][N:50]([CH3:55])[CH2:49]3)[C:40](=[O:44])[N:41]([CH3:43])[CH:42]=1)(=[O:3])[CH3:2]