huagongshe.com
HRID1919433

反应详情

EQUATION

反应方程式

HRID 1919433 的结构方程式

REACTANTS

反应物

2
结构：[N-]=[N+]=[N-].[Na+]
HCID33557

未命名化合物

结构：CCOC(=O)OCCOC(=O)C(OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCCl
HCID131729674

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)OCCOC(=O)[C@H](OCc1ccccc1)C(C)(C)COS(=O)(=O)CCCN=[N+]=[N-]
HCID86628901

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Following the general procedure for the preparation of azides of Description 16, (ethoxycarbonyloxy)ethyl (2R/S)-4-[(3-chloropropyl)sulfonyloxy]-3,3-dimethyl-2-(phenylmethoxy)butanoate (37a) (4.5 g max.) dissolved in 50 mL of anhydrous dimethyl sulfoxide (DMSO) was reacted with 0.88 g (13.5 mmol) of sodium azide (NaN3). After work-up, the crude title compound (37b) was obtained and used in the next step without further purification. The analytical data was consistent with the data obtained for (ethoxycarbonyloxy)ethyl (2R)-4-[(3-azidopropyl)sulfonyloxy]-3,3-dimethyl-2-(phenylmethoxy)butanoate (32b).

WORKUP

后处理

  1. customAfter work-up, the crude title compound (37b) was obtained
  2. customused in the next step without further purification