反应详情

Following the general procedure for the hydrogenolysis of benzyl ethers of Description 18, a mixture of (ethoxycarbonyloxy)ethyl (2R/S)-4-{[3-(acetylamino)propyl]sulfonyloxy}-3,3-dimethyl-2-(phenylmethoxy)butanoate (37c) (1.7 g, 3.3 mmol) and 1.4 g of 10 wt.-% of palladium on activated carbon in 30 mL of methanol (MeOH) was stirred overnight under a hydrogen atmosphere. After purification by mass-guided preparative HPLC, 500 mg (35% yield) of the title compound (37) was obtained as a yellow viscous oil after lyophilization of the solvents. The analytical data was consistent with the data obtained for (ethoxycarbonyloxy)ethyl (2R)-4-{[3-(acetylamino)propyl]sulfonyloxy}-2-hydroxy-3,3-dimethylbutanoate (32).

1. customAfter purification by mass-guided preparative HPLC