Hydrochloric Acid → HCID 131724360, compound

HRID 1919486Notes

Reaction equation

HRID 1919486 reaction equation
CC(C)(OC([NH:7][C@H:8]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([F:32])=[C:28]([F:33])[CH:27]=1)[CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]2[CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[N:20]=[C:14]2[CH2:13]1)=[O:11])=O)C.[ClH:35]>CO>[ClH:35].[ClH:35].[NH2:7][C@H:8]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([F:32])=[C:28]([F:33])[CH:27]=1)[CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]2[CH:18]=[C:19]([C:21]([F:22])([F:24])[F:23])[N:20]=[C:14]2[CH2:13]1)=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 670584817-[(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(3,4-difluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

Product 1

HCID 131724360HCID 131724360, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 7-[(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(3,4-difluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-c]pyrazine (110.8 mg, 0.226 mmol, from Step C) was added 2 mL of methanol saturated with hydrogen chloride. The reaction was stirred at ambient temperature for 1 h. Concentration gave 89.5 mg of the title compound as a foamy solid. 1H NMR (500 MHz, CD3OD) δ 2.97-3.10 (m, 4H), 3.91-4.34 (m, 5H), 4.90-5.04 (m, 2H), 7.16-7.33 (m, 2H), 8.01-8.08 (m, 1H). ESI-MS 389 (M+1).

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-b4fff60e7da6499b882795a98e9d477d
Source dataset
uspto-grants-2012_05
Patent number
US08168637B2

Reaction notes

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