反应详情

5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-7-carbohydrazide (24 mg) was stirred in triethylorthoformate (1 ml) at 120° C. for 4 hours. The solid was filtered and triturated in CH2Cl2/MeOH. Impurities (mainly starting material) were removed by filtration and the filtrate containing the expecting compound was concentrated. The material was purified by preparative TLC on silica gel (5% methanol in CH2Cl2) to afford N-(3-chlorophenyl)-7-(1,3,4-oxadiazol-2-yl)benzo[c][2,6]naphthyridin-5-amine as a solid (8 mg). LCMS (ES): >95% pure, m/z 374 [M+1]+.

1. filtrationThe solid was filtered
2. customtriturated in CH2Cl2/MeOH
3. customImpurities (mainly starting material) were removed by filtration
4. additionthe filtrate containing the expecting compound
5. concentrationwas concentrated
6. customThe material was purified by preparative TLC on silica gel (5% methanol in CH2Cl2)