Benzoyl Peroxide → 2-(4-Bromo-3-bromomethyl-phenyl)-propan-2-ol

HRID 1920021Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1920021
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][C:3]=1[CH3:12].[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:9])[CH3:10])=[CH:4][C:3]=1[CH2:12][Br:13]

Komponenten

5

Edukt 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 574198672-(4-Bromo-3-methylphenyl)propan-2-ol

Produkt 1

HCID 574198682-(4-Bromo-3-bromomethyl-phenyl)-propan-2-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

2-(4-Bromo-3-methyl-phenyl)-propan-2-ol (0.916 g, 4.0 mmol) in CCl4 (30 mL) was treated with N-bromosuccinimide (0.750 g, 4.2 mmol) and benzoyl peroxide (0.050 g, 0.2 mmol), and the reaction was refluxed under a halogen lamp for 2 hours. After cooling to room temperature, the mixture was partitioned between CH2Cl2 and H2O, and the organic layer was dried, filtered, and concentrated. The residue was purified by silica gel chromatography to give the title compound.

Aufarbeitung

  1. temperaturethe reaction was refluxed under a halogen lamp for 2 hours
  2. customthe mixture was partitioned between CH2Cl2 and H2O
  3. customthe organic layer was dried
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThe residue was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-8868db8d757843f699f58709b1bc5d92
Quelldatensatz
uspto-grants-2012_05
Patentnummer
US08168678B2

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