反应详情

2-(4-Bromo-3-methyl-phenyl)-propan-2-ol (0.916 g, 4.0 mmol) in CCl4 (30 mL) was treated with N-bromosuccinimide (0.750 g, 4.2 mmol) and benzoyl peroxide (0.050 g, 0.2 mmol), and the reaction was refluxed under a halogen lamp for 2 hours. After cooling to room temperature, the mixture was partitioned between CH2Cl2 and H2O, and the organic layer was dried, filtered, and concentrated. The residue was purified by silica gel chromatography to give the title compound.

1. temperaturethe reaction was refluxed under a halogen lamp for 2 hours
2. customthe mixture was partitioned between CH2Cl2 and H2O
3. customthe organic layer was dried
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by silica gel chromatography