反应详情

To a suspension of 5-(2,4-dimethyl-1,3-thiazol-5-yl)-2,4(1H,3H)-pyrimidinedione (Prep34, 250 mg, 1.120 mmol) in N,N-Dimethylformamide (DMF) (4 mL), Potassium carbonate (124 mg, 0.896 mmol) was added and the mixture was stirred at rt for 1 hour. Afterwards 3-bromo-1,1-bis(methyloxy)propane (0.170 mL, 1.120 mmol) was added dropwise and the reaction mixture was stirred at rt overnight. The day after the reaction was quenched with water and extracted with AcOEt. Organic phase was dried over Na2SO4 and concentrated under vacuum providing a crude as a clear oil. The latter was purified by flash chromatography (eluent:DCM/MeOH/NH3 97:3:0.1) affording the title compound (155 mg, 0.429 mmol) as a white solid.

1. additionwas added
2. stirringthe reaction mixture was stirred at rt overnight
3. customThe day after the reaction was quenched with water
4. extractionextracted with AcOEt
5. dry with materialOrganic phase was dried over Na2SO4
6. concentrationconcentrated under vacuum
7. customproviding a crude as a clear oil
8. customThe latter was purified by flash chromatography (eluent:DCM/MeOH/NH3 97:3:0.1)