反应详情

5-(4-methyl-1,3-thiazol-2-yl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E39, 5.8 mg, 0.012 mmol) was suspended in Diethyl ether (1 ml) and treated with 1 M HYDROCHLORIC ACID (0.015 ml, 0.015 mmol) in Et2O. The precipitate formed was triturated with Et2O (3×04 mL) and dried to afford the title compound as a grayish solid (6 mg, 88% yield).

1. customThe precipitate formed
2. customwas triturated with Et2O (3×04 mL)
3. customdried