反应详情

6-(2-Fluoropyrimidin-4-yloxy)-1-naphthoic acid (step a, 1 g, 3.53 mmol) was suspended in THF (10 mL) and warmed to partially dissolve. The mixture was cooled to RT and N-methylamine (2 M in THF, 8.9 mL, 17.7 mmol) was added. After 2 h, the solvent was concentrated in-vacuo. The residue was diluted with H2O and made pH 7 using 1 N HCl. The solid was filtered and rinsed with water and Et2O to yield the title compound as a pink solid.

1. temperaturewarmed
2. dissolutionto partially dissolve
3. concentrationthe solvent was concentrated in-vacuo
4. additionThe residue was diluted with H2O
5. filtrationThe solid was filtered
6. washrinsed with water and Et2O