反应详情

温度

140 °C

A mixture of 2-[2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy]ethyl benzoate (150 mg), 4-[(6-methylpyridin-3-yl)oxy]-3-(trifluoromethyl)aniline (175 mg) and 1-methyl-2-pyrrolidone (0.863 mL) was stirred with heating at 140° C. for 2.5 hrs. The reaction mixture was diluted with ethyl acetate (80 mL) and washed with aqueous sodium hydrogen carbonate (30 mL). The organic layer was separated, dried over magnesium sulfate and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/methanol=100/0→90/10). The object fraction was concentrated under reduced pressure. The obtained residue was dissolved in methanol (1.9 mL), 1N sodium hydroxide (0.433 mL) was added, and the mixture was stirred at room temperature for 1.5 hrs. 1N hydrochloric acid (0.433 mL) was added, and the mixture was diluted with ethyl acetate (80 mL) and washed with saturated brine (30 mL). The organic layer was dried over magnesium sulfate. After concentration under reduced pressure, the residue was subjected to silica gel column chromatography (ethyl acetate/methanol=100/0→90/10) and crystallized from diisopropyl ether to give the title compound (118 mg).

1. washwashed with aqueous sodium hydrogen carbonate (30 mL)
2. customThe organic layer was separated
3. dry with materialdried over magnesium sulfate
4. customevaporated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (ethyl acetate/methanol=100/0→90/10)
6. concentrationThe object fraction was concentrated under reduced pressure
7. dissolutionThe obtained residue was dissolved in methanol (1.9 mL)
8. addition1N sodium hydroxide (0.433 mL) was added
9. stirringthe mixture was stirred at room temperature for 1.5 hrs
10. addition1N hydrochloric acid (0.433 mL) was added
11. additionthe mixture was diluted with ethyl acetate (80 mL)
12. washwashed with saturated brine (30 mL)
13. dry with materialThe organic layer was dried over magnesium sulfate
14. concentrationAfter concentration under reduced pressure
15. customcrystallized from diisopropyl ether