反应详情

To a flask was added 4-[(4-methylpiperazin-1-yl)methyl]-N-{6-methyl-5-[(4-(3-pyridyl)-2-pyrimidyl)amino]-3-pyridyl}benzamide (2.0 g), methanesulfonic acid (0.40 g) and methanol (100 mL). After the solution was clear, the reaction mixture was concentrated under reduced pressure to about 20 mL and acetone was added to get a crystal. Filtrated and the solid was dried to give 4-[(4-methylpiperazin-1-yl)methyl]-N-{6-methyl-5-[(4-(pyrid-3-yl)pyrimid-2-yl)amino]pyrid-3-yl} benzamide methanesulfonic acid salt (2.0 g).

1. concentrationthe reaction mixture was concentrated under reduced pressure to about 20 mL and acetone
2. additionwas added
3. customto get a crystal
4. filtrationFiltrated
5. customthe solid was dried