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HRID1926994

反应详情

EQUATION

反应方程式

HRID 1926994 的结构方程式

REACTANTS

反应物

2
结构：CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)O
HCID2724772

未命名化合物

结构：CC(C)[C@H](N)C(=O)NC[C@@H](O)CP(=O)(CC1CCCCC1)OCc1ccccc1.Cl
HCID68621821

未命名化合物

PRODUCTS

生成物

1
结构：CCC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)NC[C@@H](O)CP(=O)(CC1CCCCC1)OCc1ccccc1)C(C)C
HCID68621212

未命名化合物

PROCEDURE

实验过程

The title compound was prepared substantially in a similar manner as Step 1, Example 10 using N-Z-Ile-OH and [(R)-3-((S)-2-amino-3-methyl-butyrylamino)-2-hydroxy-propyl]-cyclohexylmethyl-phosphinic acid benzyl ester hydrochloride as the starting materials. The title compound was purified by SiO2 chromatography using 0-4% MeOH/CH2Cl2 as the eluent. 1H NMR (CD3OD, 300 MHz): δ 7.3 (m, 10H), 5.2-4.95 (m, 4H), 4.17 (d, 1H), 4.12 (m, 1H), 3.95 (d, 1H), 3.20 (m, 2H), 2.12-2.01 (m, 1H), 1.90-1.76 (m, 3H), 1.70-1.61 (m, 6H), 1.55-1.47 (m, 3H), 1.36-1.14 (m, 4H), 1.11-0.95 (m, 14H). 31P NMR (CD3OD, 300 MHz): δ 59.06, 58.33. LCMS m/z: [M+H]+=672.

WORKUP

后处理

  1. customThe title compound was purified by SiO2 chromatography