反应详情

温度

23 °C

To N-tert-butyl-3-{6-[4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-pyridin-2-yl}-benzenesulfonamide (Example 418) (0.250 g, 0.475 mmol) was added TFA (3 mL) and the reaction mixture was stirred at 23° C. for 3 h. The mixture was partitioned between EtOAc and saturated NaHCO3 solution, the organic layer was dried over MgSO4. Removal of the solvent in vacuum left a crude product which was triturated with diethyl ether to give the title compound as a white solid (0.223 g, 100%). MS (ISP) 471.2 [(M+H)+]; mp 239° C. (dec.).

1. customThe mixture was partitioned between EtOAc and saturated NaHCO3 solution
2. dry with materialthe organic layer was dried over MgSO4
3. customRemoval of the solvent in vacuum
4. waitleft a crude product which
5. customwas triturated with diethyl ether