反应详情

温度

100 °C

In a microwave vial was 1-tert-butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate (0.577 g, 2.24 mmol, Example 7c), Sodium ethoxide (0.153 g, 2.24 mmol), and 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (0.55 g, 2.24 mmol) added in ethanol (10 mL) to give a suspension. The reaction was heated in the microwave oven for 20 min at 100° C. Solvent was evaporated under reduced pressure. The crude was dissolved in minimal volume of EtOH and few drops of water added to allow the product to precipitate. The precipitated product was filtered and dried to give tert-butyl 4-hydroxy-2-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (0.400 g, 39.4%). MS (ESI+)/(ESI−) m/z 453/450

1. customto give a suspension
2. customSolvent was evaporated under reduced pressure
3. dissolutionThe crude was dissolved in minimal volume of EtOH and few drops of water
4. additionadded
5. customto precipitate
6. filtrationThe precipitated product was filtered
7. customdried