反应详情

4-[4-(4-Acetyl-3-methyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester was prepared according to General Procedure B by the reaction of 4-(4-chloro-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (Intermediate 19) with 4′-hydroxy-2′-methylacetophenone (available from Aldrich Chemical Company, Inc., Milwaukee, Wis., USA) in dimethylformamide. 1H NMR (400 MHz, DMSO-d6) δ 1.43 (s, 9H), 1.97-2.06 (m, 4H), 2.33 (s, 3H), 2.67 (s, 3H), 2.94-3.04 (m, 2H), 4.04-4.10 (m, 2H), 4.98-5.04 (m, 1H), 7.29-7.31 (m, 2H), 7.96-7.98 (m, 1H), 8.29 (s, 1H), 8.55 (s, 1H). Mass spectrum MH+=452.