反应详情

2,2,2-Trifluoro-1-{4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-ethanone was prepared according to General Procedure J by the reaction of 4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (Example 59) with trifluoroacetic acid, followed by reaction of the resulting amine with trifluoroacetic anhydride (available from Alfa Aesar, Ward Hill, Mass., USA). 1H NMR (400 MHz, DMSO-d6) δ 2.10-2.16 (m, 4H), 3.55-3.65 (m, 1H), 4.00-4.04 (m, 1H), 4.41-4.44 (m, 1H), 5.18-5.24 (m, 1H), 7.63-7.65 (m, 2H), 8.05-8.07 (m, 2H), 8.41 (s, 1H), 8.58 (s, 1H). Mass spectrum MH+=470.